| Date & Time | Favorite | Spread | Underdog | Total | Money Odds |
| 9/28 1:00 ET | Denver | -9.5 | At Kansas City | 46.5 | -$450 +$350 |
| 9/28 1:00 ET | At Cincinnati | -3.5 | Cleveland | 44.5 | -$185 +$165 |
| 9/28 1:00 ET | At Jacksonville | -8 | Houston | 42 | -$350 +$290 |
| 9/28 1:00 ET | At NY Jets | -1.5 | Arizona | 45 | -$125 +$105 |
| 9/28 1:00 ET | At New Orleans | -6 | San Francisco | 48.5 | -$260 +$220 |
| 9/28 1:00 ET | At Carolina | -7 | Atlanta | 39.5 | -$320 +$260 |
| 9/28 1:00 ET | At Tennessee | -3 | Minnesota | 36.5 | -$155 +$135 |
| 9/28 1:00 ET | At Tampa Bay | -1 | Green Bay | 43 | -$120 +$100 |
| 9/28 4:05 ET | Buffalo | -8 | At St. Louis | 41.5 | -$370 +$320 |
| 9/28 4:05 ET | San Diego | -8 | At Oakland | 45.5 | -$330 +$270 |
| 9/28 4:15 ET | At Dallas | -11 | Washington | 46 | -$500 +$400 |
| 9/28 8:15 ET | Philadelphia | -3 | At Chicago | Off | Off |
| Monday Night Football Odds | |||||
| 9/29 8:35 ET | At Pittsburgh | -7 | Baltimore | Off | Off |